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Research Group "Angewandte Physik - Biophysik, TU Wien"
(Univ.Prof. DI. Dr. Gerhard Schütz)

Head of the research group:
Last name:Schütz
First name(s):Gerhard
Title (leading):Univ.Prof. DI. Dr.
Institution:Vienna University of Technology
Organizational unit:Institut für Angewandte Physik
Street address:Wiedner Hauptstraße 10
Postal code:1040
Assignments to Research Areas:
Research area(s):
  • Medical, Environmental and Bio-Physics
Assignments to Fields of Work According to the Austrian System of Science Areas:
Field(s) of work:
  • Biophysics (106006)
Data Acquisition:
Date of the data acquisition:27.05.2011
Data acquisition period:from: 2008   up to including: 2012
Research Group at the Time of the Data Acquisition:
Scientific group members:
7 Persons
Dr. Mario Brameshuber
Dr. Eva Sevcsik
Dr. Enrico Klotzsch
Dr. Birgit Plochberger
D.I. Stefan Sunzenauer
Mag. Andreas Anderluh
Elena Parkinson
Full-time equivalents:7
Percentage project-funded:60
Scientific Output in the Above Data Acquisition Period:
H-index of the group head:23
Number of publications:33
Five most important publications:
  1. J. B. Huppa, M. Axmann, M. A. Mörtelmaier, B. F. Lillemeier, E. W. Newell, M. Brameshuber, L. O. Klein, G. J. Schütz, M. M. Davis,Nature 463 (2010) 963-967,TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
  2. M. Schwarzenbacher, M. Kaltenbrunner, M. Brameshuber, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stockinger, G. J. Schütz, Nat. Methods 5 (2008) 1053-1060, Micropatterning for quantitative analysis of protein-protein interactions in living cells
  3. J. Madl, J. Weghuber, R. Fritsch, I. Derler, M. Fahrner, I. Frischauf, B. Lackner, C. Romanin, G. J. Schütz, J. Biol. Chem. 285 (2010) 41135-41142, Resting-state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells
  4. M. Brameshuber, J. Weghuber, V. Ruprecht, I. Gombos, I. Horváth, L. Vigh, P. Eckerstorfer, E. Kiss, H. Stockinger, G. J. Schütz, J. Biol. Chem. 285 (2010) 41765-41771, Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane
  5. L. Zimmermann, W. Paster, J. Weghuber, P. Eckerstorfer, H. Stockinger, G. J. Schütz, J. Biol. Chem. 285 (2010) 6063-6070, Direct observation and quantitative analysis of Lck-exchange between plasma membrane and cytosol in living T cells
Projects and Funding Granted in the Above Data Acquisition Period:
Competitive projects:
  • FWF:
    Development of a compact microarray readout device with single-molecule sensitivity
    Laufzeit: 2007 - 2010;´Mittel: 78 kEuro
  • FWF:
    Subunit stoichiometry and supermolecular organization of transmembrane transporters (SFB35)
    Laufzeit: 2012-2014; Mittel: 220kEuro
  • FWF/ESF:
    Lipid-protein interactions in membrane organisation - Detecting rafts in the live cell plasma membrane: from resting state to signaling
    Laufzeit: 2009 - 2012; Mittel: 224 kEuro
  • FWF/ESF:
    Molecular level physiology and pathology of oxidized phospholipids - single molecule tracking of oxidized phospholipids in the live cell plasma membrane
    Laufzeit: 2009 - 2012; Mittel: 230 kEuro
  • EU:
    Lipid droplets as dynamic organelles of fat deposition and release: Translational research towards human disease
    Laufzeit: 2008 - 2012; Mittel: 130 kEuro
  • BMBWK:
    Ultra-sensitive proteomics and genomics: Development of a next generation proteomics and genomics platform - combination of ultra-sensitive methods for chip-based characterization and diagnostics
    Laufzeit: 2002 - 2006; Mittel: 1.850 kEuro
  • BMWK:
    Ultra-sensitive proteomics and genomics II: Application of a next generation proteomics and genomics platform for selected projects within the Austrian bioscience community
    Laufzeit: 2006 - 2009; Mittel: 777 kEuro
  • BMWF:
    Ultra-sensitive proteomics and genomics III: towards correlated analysis of structure, function and content of single cells
    Laufzeit: 2009 - 2012; Mittel: 375 kEuro
Commissioned projects:
  • Intercell GmbH:
    Characterization of the effects of the immunostimulatory cationic peptide KLK on the cellular recycling machinery and plasma-membrane organization
    Laufzeit: 2008 - 2009; Mittel: 30 kEuro
Funded awards:
  • START:
    Immunology at a Nanoscopic View: A Single-Molecule Approach
    Laufzeit: 2004 - 2010; Mittel: 1.200 kEuro
Research Topics:
Current research topics:
  • Einzelmolekülmikroskopie
  • Immunologie
  • Biophysik
Future topics (next 5 years):
  • Einzelmolekülmikroskopie
  • Immunologie
  • Biophysik
Teaching and Research Mobility in the Above Data Acquisition Period:
Doctor's theses:
9 doctor's theses
  1. Stefan Wieser, JKU, 2009
  2. Mario Brameshuber, JKU, 2009
  3. Markus Axmann, JKU, 2009
  4. Jaroslaw Jacak, JKU, 2009
  5. Lars Zimmermann, JKU, 2010
  6. Verena Ruprecht, JKU, 2010
  7. Birgit Plochberger, JKU, 2010
  8. Josef Madl, JKU, 2011
  9. Clemens Hesch, JKU, 2011
Diploma and master theses:
8 theses
  1. Reinhard Grurl, JKU, 2008
  2. Daniel Bergmair, JKU, 2009
  3. Stefan Sunzenauer, JKU, 2009
  4. Jacqueline Stadlbauer, University of Applied Sciences Linz, 2009
  5. Michael Sams, University of Applied Sciences Linz, 2009
  6. Magdalena Sturm, University of Applied Sciences Linz, 2009
  7. Clemens Grünsteidl, JKU, 2011
  8. Petra Seyer, JKU, 2012
International networking:
  • Manuel Mörtelmaier (outgoing): Stanford 2005
  • Mario Brameshuber (outgoing): Stanford 2010
  • Markus Axmann (outgoing): MPI Stuttgart 2010
  • Bracha Halaf (incoming): Weizmann Institute 2008
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